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Proceedings Paper

False-positive reduction using Hessian features in computer-aided detection of pulmonary nodules on thoracic CT images
Author(s): Berkman Sahiner; Zhanyu Ge; Heang-Ping Chan; Lubomir M. Hadjiiski; Naama Bogot; Philip N. Cascade; Ella A. Kazerooni
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Paper Abstract

We are developing a computer-aided detection (CAD) system for lung nodules in thoracic CT volumes. During false positive (FP) reduction, the image structures around the identified nodule candidates play an important role in differentiating nodules from vessels. In our previous work, we exploited shape and first-order derivative information of the images by extracting ellipsoid and gradient field features. The purpose of this study was to explore the object shape information using second-order derivatives and the Hessian matrix to further improve the performance of our detection system. Eight features related to the eigenvalues of the Hessian matrix were extracted from a volume of interest containing the object, and were combined with ellipsoid and gradient field features to discriminate nodules from FPs. A data set of 82 CT scans from 56 patients was used to evaluate the usefulness of the FP reduction technique. The classification accuracy was assessed using the area Az under the receiving operating characteristic curve and the number of FPs per section at 80% sensitivity. In the combined feature space, we obtained a test Az of 0.97 ± 0.01, and 0.27 FPs/section at 80% sensitivity. Our results indicate that combining the Hessian, ellipsoid and gradient field features can significantly improve the performance of our FP reduction stage.

Paper Details

Date Published: 29 April 2005
PDF: 6 pages
Proc. SPIE 5747, Medical Imaging 2005: Image Processing, (29 April 2005); doi: 10.1117/12.595714
Show Author Affiliations
Berkman Sahiner, Univ. of Michigan (United States)
Zhanyu Ge, Univ. of Michigan (United States)
Heang-Ping Chan, Univ. of Michigan (United States)
Lubomir M. Hadjiiski, Univ. of Michigan (United States)
Naama Bogot, Univ. of Michigan (United States)
Philip N. Cascade, Univ. of Michigan (United States)
Ella A. Kazerooni, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 5747:
Medical Imaging 2005: Image Processing
J. Michael Fitzpatrick; Joseph M. Reinhardt, Editor(s)

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