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Proceedings Paper

Small animal imaging using a flat panel detector-based cone beam computed tomography (FPD-CBCT) imaging system
Author(s): David L. Conover; Ruola Ning; Yong Yu; Xianghua Lu; Ronald W. Wood; Jay E. Reeder; Aimee M. Johnson
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Paper Abstract

Flat panel detector-based cone beam CT (FPD-CBCT) imaging system prototypes have been constructed based on modified clinical CT scanners (a modified GE 8800 CT system and a modified GE HighSpeed Advantage (HSA) spiral CT system) each with a Varian PaxScan 2520 imager. The functions of the electromechanical and radiographic subsystems of the CT system were controlled through specially made hardware, software and data acquisition modules to perform animal cone beam CT studies. Small animal (mouse) imaging studies were performed to demonstrate the feasibility of an optimized CBCT imaging system to have the capability to perform longitudinal studies to monitor the progression of cancerous tumors or the efficacy of treatments. Radiographic parameters were optimized for fast (~10 second) scans of live mice to produce good reconstructed image quality with dose levels low enough to avoid any detectable radiation treatment to the animals. Specifically, organs in the pelvic region were clearly imaged and contrast studies showed the feasibility to visualize small vasculature and space-filling bladder tumors. In addition, prostate and mammary tumors were monitored in volume growth studies.

Paper Details

Date Published: 20 April 2005
PDF: 12 pages
Proc. SPIE 5745, Medical Imaging 2005: Physics of Medical Imaging, (20 April 2005); doi: 10.1117/12.595582
Show Author Affiliations
David L. Conover, Univ. of Rochester Medical Ctr. (United States)
Ruola Ning, Univ. of Rochester Medical Ctr. (United States)
Yong Yu, Univ. of Rochester Medical Ctr. (United States)
Xianghua Lu, Univ. of Rochester Medical Ctr. (United States)
Ronald W. Wood, Univ. of Rochester Medical Ctr. (United States)
Jay E. Reeder, Univ. of Rochester Medical Ctr. (United States)
Aimee M. Johnson, Univ. of Rochester Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 5745:
Medical Imaging 2005: Physics of Medical Imaging
Michael J. Flynn, Editor(s)

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