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Proceedings Paper

Spectroscopic luminescent tomographic imaging for quantitative assessment of hemoglobin oxygenation
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Paper Abstract

Healthy tissues and tumors exhibit different optical characteristics in blood volume and oxygen sufficiency. Tumor physiology is effectively monitored by non-invasively observing the changes in oxyhemoglobin and deoxyhemoglobin concentration in tissue. In this paper, we present a practical method for quantitative assessment of hemoglobin concentration and blood oxygenation based on the diffusion theory and finite element analysis. The method incorporates prior knowledge on permissible target region, and reduced the reconstruction of chromosphere concentration to an optimization procedure with simple constrain. A numerical simulation study has been conducted by using a heterogeneous phantom. The numerical results show that the reconstruction method has been successfully applied for the reconstruction of the variation of HbO2 and HbR concentration in numerical simulation experiments.

Paper Details

Date Published: 20 April 2005
PDF: 6 pages
Proc. SPIE 5745, Medical Imaging 2005: Physics of Medical Imaging, (20 April 2005); doi: 10.1117/12.595427
Show Author Affiliations
Wenxiang Cong, Univ. of Iowa (United States)
Durairaj Kumar, Univ. of Iowa (United States)
Alexander Cong, Univ. of Iowa (United States)
Ge Wang, Univ. of Iowa (United States)


Published in SPIE Proceedings Vol. 5745:
Medical Imaging 2005: Physics of Medical Imaging
Michael J. Flynn, Editor(s)

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