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Proceedings Paper

CAD system for lung cancer screening using low dose thick-slice CT images
Author(s): Mitsuru Kubo; Nobuhiro Yamada; Yoshiki Kawata; Noboru Niki; Kenji Eguchi; Hironobu Ohmatsu; Masahiro Kaneko; Masahiko Kusumoto; Ryutaro Kakinuma; Hiroyuki Nishiyama; Noriyuki Moriyama
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Paper Abstract

Our group developed the computer aided diagnosis (CAD) system for lung cancer in 1996, and has been used in clinical field since 1997. From this CAD system (conventional system), we discovered problem and we attempted to solve the problem by using our proposed algorithm. The proposed algorithm succeeded in the improvement of the following three problems of the conventional system. (1) Weak extraction algorithm of region of interest (ROI) with noise, (2) Poor knowledge of chest structure, and (3) diagnostic processing for nodule of limited size. In this paper, the algorithm that solves problem (2) and (3) is described. We evaluated the proposed algorithm, which was applied to the following four databases. (A) Lung cancer database, (B) detailed examination database, (C) a large-scale screening database by 10mm-thickness images reconstructed from single-slice CT scan, and (D) a large-scale screening database by 10mm-thickness images reconstructed from multi-slice CT scan. The proposed method obtained the following successful results: Lung cancer database 95.7% TP and detailed examination 94.8% TP. For the large-scale screening database, we evaluated each examination process from physicians’ reading to cancer decision. The extraction rate of proposed algorithm improved as the examinations proceed. Two false positive results were obtained. False positive 1 (6.8-9.2 shadows/case) needed for a detailed examination and the object of false positive 2 (2.6-4.0 shadows/case) was an abnormal shadow.

Paper Details

Date Published: 29 April 2005
PDF: 8 pages
Proc. SPIE 5747, Medical Imaging 2005: Image Processing, (29 April 2005); doi: 10.1117/12.595157
Show Author Affiliations
Mitsuru Kubo, Univ. of Tokushima (Japan)
Nobuhiro Yamada, Univ. of Tokushima (Japan)
Yoshiki Kawata, Univ. of Tokushima (Japan)
Noboru Niki, Univ. of Tokushima (Japan)
Kenji Eguchi, Tokai Univ. (Japan)
Hironobu Ohmatsu, National Cancer Ctr. Hospital East (Japan)
Masahiro Kaneko, National Cancer Ctr. Research Ctr. for Cancer Prevention and Screening (Japan)
Masahiko Kusumoto, National Cancer Ctr. Research Ctr. for Cancer Prevention and Screening (Japan)
Ryutaro Kakinuma, National Cancer Ctr. (Japan)
Hiroyuki Nishiyama, Social Health Insurance Medical Ctr. (Japan)
Noriyuki Moriyama, National Cancer Ctr. Research Ctr. for Cancer Prevention and Screening (Japan)


Published in SPIE Proceedings Vol. 5747:
Medical Imaging 2005: Image Processing
J. Michael Fitzpatrick; Joseph M. Reinhardt, Editor(s)

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