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Proceedings Paper

Determination of left ventricular ejection fraction in technetium-99m-methoxy isobutyl isonitrile radionuclide angiocardiography
Author(s): Malcolm H. Davis; Bahman Rezaie; Frederick L. Weiland
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Paper Abstract

Abnormal left ventricular function is a diagnostic indication of cardiac disease. Left ventricular function is most commonly quantified by ejection fraction measurements. This paper presents a novel approach for the measurement of left ventricular ejection fraction (L VEF) using the recently introduced myocardial imaging agent, technetium-99m methoxy isobutyl isonitrile (99mTc-sestamibi). The approach utilizes computer image processing techniques to determine L VEF in equilibrium 99mTc-sestamibi multiple gated radionuclide angiography (RNA). Equilibrium RNA is preferred to first-pass RNA techniques due to the higher signal-to-noise ratio of equilibrium RNA resulting from longer image acquisition times. Data from 23 patients, symptomatic of cardiac disease, indicate that L VEFs determined using this radionuclide technique correlate well with contrast x-ray single plane cineangiography (r equals 0.83, p < 0.0000003).

Paper Details

Date Published: 1 June 1992
PDF: 16 pages
Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992); doi: 10.1117/12.59459
Show Author Affiliations
Malcolm H. Davis, St. Mary's Univ. (United States)
Bahman Rezaie, St. Mary's Univ. (United States)
Frederick L. Weiland, U.S. Air Force Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 1652:
Medical Imaging VI: Image Processing
Murray H. Loew, Editor(s)

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