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Proceedings Paper

Registration of high-resolution images of the retina
Author(s): Artur V. Cideciyan; Samuel G. Jacobson; Colin M. Kemp; Robert W. Knighton; Joachim H. Nagel
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Paper Abstract

A method of image registration is presented for the case when the deformation between two images can be well approximated with a combination of translation, rotation, and global scaling. The method achieves very high accuracy by combining a global optimization in the 4- dimensional discrete parameter space with a local optimization in the 4-dimensional continuous parameter space. The 4-dimensional global optimization is accomplished with two 2- dimensional optimizations. The Fourier magnitude is used to decouple translation from rotation and scaling, and a log-polar mapping of the Fourier magnitude is used to convert rotation and scaling into shifts. Optimal rotation and scaling parameters are determined with a cross-correlation in the log-polar domain. After compensation for rotation and scaling differences, cross-correlation in the spatial domain yields the translation parameters. The four registration parameters are further refined with a local optimization using the correlation coefficient as a similarity measure in the 4-dimensional continuous parameter space. Results are shown from simulations and from registration of retinal images. For simulated images with a signal-to-noise ratio of -5 dB, the accuracy of the registration method is estimated to be better than 0.07 degrees, 0.1%, and 0.3 pixels for rotation, scaling, and translation, respectively. In the case of 512 X 512 pixel images the computation resource requirements are compatible with high end PCs, i.e., approximately 25 minutes on an Intel 80486/33 MHz based IBM/PC compatible.

Paper Details

Date Published: 1 June 1992
PDF: 13 pages
Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992); doi: 10.1117/12.59439
Show Author Affiliations
Artur V. Cideciyan, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Samuel G. Jacobson, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Colin M. Kemp, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Robert W. Knighton, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Joachim H. Nagel, Univ. of Miami (United States)


Published in SPIE Proceedings Vol. 1652:
Medical Imaging VI: Image Processing
Murray H. Loew, Editor(s)

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