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Proceedings Paper

Conducting polymer as smart interfaces for cultured neurons
Author(s): Arti Ahluwalia; Ines Mauricio; Alberto Mazzoldi; Giorgio Serra; Francesca Bianchi
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Paper Abstract

This work is part of a research project aimed at realising conducting polymer matrices for interfacing with cultured neurons. The polymer matrix has a dual function, one as a medium for recording electrical activity; the other is chemical stimulation through the release of bioactive molecules. In this work we use poly-3-hexylthiophene as a conducting polymer matrix. To test the polymer’s ability to release molecules upon the application of a potential it was doped with glutamate (GA). GA is an important neurotransmitter, and its controlled release can be important in several medical and tissue engineering applications. Diffusional and controlled release of GA from the polymer were assessed. Biocompatibility of the samples was evaluated at each stage using neuroblastoma cell cultures.

Paper Details

Date Published: 6 May 2005
PDF: 8 pages
Proc. SPIE 5759, Smart Structures and Materials 2005: Electroactive Polymer Actuators and Devices (EAPAD), (6 May 2005); doi: 10.1117/12.593732
Show Author Affiliations
Arti Ahluwalia, Univ. di Pisa (Italy)
Ines Mauricio, Univ. di Pisa (Italy)
Alberto Mazzoldi, Univ. di Pisa (Italy)
Giorgio Serra, Univ. di Pisa (Italy)
Francesca Bianchi, Univ. di Pisa (Italy)

Published in SPIE Proceedings Vol. 5759:
Smart Structures and Materials 2005: Electroactive Polymer Actuators and Devices (EAPAD)
Yoseph Bar-Cohen, Editor(s)

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