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Proceedings Paper

Depth-sensitive reflectance measurements using obliquely oriented fiber probes
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Paper Abstract

Computer simulation was used to facilitate the design of fiber-probe geometries which enable enhanced detection of optical signals arising from specific tissue depths. Obtaining understanding of the relationship between fiber-probe design and tissue interrogation is critical when developing strategies for optical detection of epithelial pre-cancers which originate at known depths from the tissue surface. We investigated how the depth of optical interrogation may be controlled through combinations of collection angles, source-detector separations and numerical apertures. We found that increasing the obliquity of collection fibers at a given source-detector separation can effectively enhance the detection of superficially scattered signals. Fiber numerical aperture provides additional depth selectivity; however, the perturbations in sampling depth achieved through this means are modest relative to the changes generated by modifying the angle of collection and source-detection separation.

Paper Details

Date Published: 23 March 2005
PDF: 12 pages
Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005); doi: 10.1117/12.593655
Show Author Affiliations
Adrien Wang, Rice Univ. (United States)
Janelle Elise Bender, Rice Univ. (United States)
T. Joshua Pfefer, U.S. Food and Drug Administration (United States)
Urs. Utzinger, Univ. of Arizona (United States)
Rebekah Drezek, Rice Univ. (United States)

Published in SPIE Proceedings Vol. 5691:
Optical Fibers and Sensors for Medical Applications V
Israel Gannot, Editor(s)

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