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Proceedings Paper

The study of cerebral hemodynamic and neuronal response to visual stimulation using simultaneous NIR optical tomography and BOLD fMRI in humans
Author(s): Xiaofeng Zhang; Vladislav Y. Toronov; Monica Fabiani; Gabriele Gratton; Andrew G. Webb
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Paper Abstract

The integration of near-infrared (NIR) and functional MRI (fMRI) studies is potentially a powerful method to investigate the physiological mechanism of human cerebral activity. However, current NIR methodologies do not provide adequate accuracy of localization and are not fully integrated with MRI in the sense of mutual enhancement of the two imaging modalities. Results are presented to address these issues by developing an MRI-compatible optical probe and using diffuse optical tomography for optical image reconstruction. We have developed a complete methodology that seamlessly integrates NIR tomography with fMRI data acquisition. In this paper, we apply this methodology to determine both hemodynamic and early neuronal responses in the visual cortex in humans. Early results indicate that the changes in deoxyhemoglobin concentration from optical data are co-localized with fMRI BOLD signal changes, but changes in oxyhemoglobin concentration (not measurable using fMRI) show small spatial differences.

Paper Details

Date Published: 25 April 2005
PDF: 7 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.593435
Show Author Affiliations
Xiaofeng Zhang, Univ. of Illinois at Urbana-Champaign (United States)
Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)
Vladislav Y. Toronov, Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)
Monica Fabiani, Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)
Univ. of Illinois at Urbana-Champaign (United States)
Gabriele Gratton, Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)
Univ. of Illinois at Urbana-Champaign (United States)
Andrew G. Webb, Univ. of Illinois at Urbana-Champaign (United States)
Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)


Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong; Eugene A. Trowers; Werner T. W. de Riese; Kenton W. Gregory; Abraham Katzir; Lawrence S. Bass; Karen M. McNally-Heintzelman; Nikiforos Kollias; Reza S. Malek; Henry Hirschberg; Steen J. Madsen; Kenneth Eugene Bartels; Lloyd P. Tate, Editor(s)

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