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Proceedings Paper

Small animal bone density and morphometry analysis with a dual energy x-ray absorptiometry bone densitometer using a 2D digital radiographic detector
Author(s): V. Boudousq; T. Bordy; G. Gonon; J. M. Dinten
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Paper Abstract

The LEXXOS (DMS, Montpellier, France) is the first axial and total body cone beam bone densitometer using a 2D digital radiographic detector. Technical principles and performances for BMD measurements have been presented in previous papers. Bone densitometers are also used on small animals for drug development. In this paper, we show how the LEXXOS system can be adapted to small animals examinations, and its performances are evaluated. At first, in order to take advantage of the whole area of the digital flat panel X-ray detector, the geometrical configuration has been adapted. Secondly, as small animals present low BMD, a specific dual energy calibration has been defined. This adapted system has then been evaluated on two sets of mice: six reference mice and six ovariectomized mice. Each month, these two populations have been examined and the total body BMD has been measured. This evaluation has shown that the right order of BMD magnitude has been obtained and, as expected, BMD increases on the two sets until age of puberty and after this period, decreases significantly for the ovariectomized set. Moreover, the bone image obtained by dual energy processing on LEXXOS presents a radiographic image quality providing with useful complementary information on bone morphometry and architecture.

Paper Details

Date Published: 20 April 2005
PDF: 8 pages
Proc. SPIE 5745, Medical Imaging 2005: Physics of Medical Imaging, (20 April 2005); doi: 10.1117/12.593079
Show Author Affiliations
V. Boudousq, CHU de Nimes/Hopital Caremeau (France)
T. Bordy, CEA/LETI (France)
G. Gonon, CEA/LETI (France)
J. M. Dinten, CEA/LETI (France)


Published in SPIE Proceedings Vol. 5745:
Medical Imaging 2005: Physics of Medical Imaging
Michael J. Flynn, Editor(s)

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