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Proceedings Paper

Application of optical coherence tomography for tissue engineering
Author(s): Ying Yang; Ruikang K. Wang; Elvire Guyot; Alicia El Haj; Arnaud Dubois
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Paper Abstract

In the past decade, optical coherence tomography (OCT) has achieved a rapid development in clinical applications. Its capability of on-line measurement, non-destructive manner and high spatial resolution offers a great potential for tissue engineering in which the dynamic process of tissue growth need to be monitored on-line either for bulk constructs or at the cellular level. In this study, two OCT systems, time-domain Michelson interferometer based OCT (TD-OCT) and whole field OCT (WF-OCT) have been used to image poly(lactic acid) based scaffold and tissue engineered bone. It is demonstrated that TD-OCT is able to visualize the porous structure of the scaffold and its changes during culture at a macroscopic level, whilst the cells' distribution and morphology can be depicted clearly in WF-OCT. With the aid of an external contrast agent, magnetic beads, clearer cellular images have been obtained.

Paper Details

Date Published: 13 April 2005
PDF: 6 pages
Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.592691
Show Author Affiliations
Ying Yang, Keele Univ. Medical School (United Kingdom)
Ruikang K. Wang, Cranfield Univ. at Silsoe (United Kingdom)
Elvire Guyot, Ecole Superieure de Physique et de Chimie Industrielles (France)
Alicia El Haj, Keele Univ. Medical School (United Kingdom)
Arnaud Dubois, Ecole Superieure de Physique et de Chimie Industrielles (France)


Published in SPIE Proceedings Vol. 5690:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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