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Proceedings Paper

Study of action of cyclophosphamide and extract of mycelium of Pleurotus ostreatus in vivo on mice, bearing melanoma B16-F0-GFP
Author(s): Irina G. Meerovich; Meng Yang; Ping Jiang; Robert M. Hoffman; Valery P. Gerasimenya; Alexander E. Orlov; Alexander P. Savitsky; Vladimir O. Popov
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Paper Abstract

In this work we studied in vivo the combined action of cyclophosphamide and the extract of mycelium of Pleurotus ostreatus on mice bearing melanoma B16-F0, expressing green fluorescent protein (GFP). This model allows to recognize small-size tumors and metastases, unrecognizable by other methods. It was found that combined administration of cyclophosphamide (300 mg/kg) and the extract of mycelium of Pleurotus ostreatus (100 mg/kg), administered for 10 days after cyclophosphamide injection, as well administration of cyclophosphamide alone, cause inhibition of tumor growth about 97%. It was shown that administration of the extract of mycelium of Pleurotus ostreatus alone leads to inhibition of tumor growth of 61%. It was found that in case of combined administration of cyclophosphamide and the extract of mycelium of Pleurotus ostreatus, leucopenia was less expressed than in case of administration of cyclophosphamide alone.

Paper Details

Date Published: 4 April 2005
PDF: 8 pages
Proc. SPIE 5704, Genetically Engineered and Optical Probes for Biomedical Applications III, (4 April 2005); doi: 10.1117/12.592546
Show Author Affiliations
Irina G. Meerovich, A.N. Bach Institute of Biochemistry (Russia)
Meng Yang, AntiCancer, Inc. (United States)
Ping Jiang, AntiCancer, Inc. (United States)
Robert M. Hoffman, AntiCancer, Inc. (United States)
Valery P. Gerasimenya, Pulmomed JSV (Russia)
Alexander E. Orlov, Pulmomed JSV (Russia)
Alexander P. Savitsky, A.N. Bach Institute of Biochemistry (Russia)
Vladimir O. Popov, A.N. Bach Institute of Biochemistry (Russia)


Published in SPIE Proceedings Vol. 5704:
Genetically Engineered and Optical Probes for Biomedical Applications III
Darryl J. Bornhop; Samuel I. Achilefu; Ramesh Raghavachari; Alexander P. Savitsky, Editor(s)

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