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Proceedings Paper

Optical tomography using independent component analysis to detect absorptive, scattering, or fluorescent inhomogeneities in turbid media
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Paper Abstract

A new imaging approach for three-dimensional localization and characterization of absorptive, scattering or fluorescent objects in a turbid medium is presented and demonstrated using simulated and experimental data. This approach uses a multi-source and multi-detector signal acquisition scheme and independent component analysis (ICA) from information theory for target localization and characterization. Independent component analysis of the perturbation in the spatial intensity distribution or the fluorescent signal measured on the medium boundary sorts out the embedded objects. The location and optical characteristics (size, shape and optical property) of the embedded objects are obtained from a Green's function analysis based on an appropriate model for light propagation in the background medium and back-projections of the retrieved independent components.

Paper Details

Date Published: 28 April 2005
PDF: 8 pages
Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.592153
Show Author Affiliations
M. Xu, City College/CUNY (United States)
M. Alrubaiee, City College/CUNY (United States)
S. K. Gayen, City College/CUNY (United States)
R. R. Alfano, City College/CUNY (United States)

Published in SPIE Proceedings Vol. 5693:
Optical Tomography and Spectroscopy of Tissue VI
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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