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Proceedings Paper

Noncontact subnanometer measurement of transient surface displacement during action potential propagation
Author(s): Taner Akkin; Digant P. Dave; H. Grady Rylander; Thomas E. Milner
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Paper Abstract

We have demonstrated non-contact, sub-nanometer optical measurement of neural surface displacement associated with action potential propagation without applying exogenous chemicals or reflection coatings. Signals recorded from crayfish leg nerve using a phase-sensitive optical low coherence reflectometer show that transient neural surface displacement due to action potential propagation is approximately 1 nm in amplitude and 1 ms in duration. Measured optical signals are coincident with electrical action potential arrival to the optical measurement site. Recent experiments indicate signals with similar amplitude and duration are observed in response to repetitive fast stimulation (200 stimuli/s).

Paper Details

Date Published: 13 April 2005
PDF: 4 pages
Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.592026
Show Author Affiliations
Taner Akkin, The Univ. of Texas at Austin (United States)
Digant P. Dave, The Univ. of Texas at Austin (United States)
H. Grady Rylander, The Univ. of Texas at Austin (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 5690:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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