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Proceedings Paper

Fluctuation correlation spectroscopy of near-field trapped nanoparticles
Author(s): Tiberiu-Dan Onuta; William L. Schaich; Bogdan G. Dragnea
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Paper Abstract

A new technique, the near-field correlation spectroscopy (NFCS), is introduced which will be useful for monitoring individual binding events between the biomolecular complex precursors and a functionalized nanoparticle core in a physiological fluid. From jumps in the measured correlation times of single particles trapped in nanoapertures in a metal film, one will be able to determine the rate of binding/dissociation events and, most importantly, the nature of the binding entity, for e.g. discriminate the arrival and binding of a pentamer from a hexamer of protein subunits. This report deals only with the initial steps that are required to implement the new technique.

Paper Details

Date Published: 14 March 2005
PDF: 5 pages
Proc. SPIE 5736, Nanomanipulation with Light, (14 March 2005); doi: 10.1117/12.591679
Show Author Affiliations
Tiberiu-Dan Onuta, Indiana Univ. (United States)
William L. Schaich, Indiana Univ. (United States)
Bogdan G. Dragnea, Indiana Univ. (United States)

Published in SPIE Proceedings Vol. 5736:
Nanomanipulation with Light
David L. Andrews, Editor(s)

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