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Proceedings Paper

Biosensing based upon molecular confinement in metallic nanocavity arrays
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Paper Abstract

We study enhancement of fluorescence of molecular species bound within metallic nanocavities. These nanostructures possess a number of desirable properties for real-time microarrays, such as localization of excitation light within the nanocavities, strong isolation from fluorescence produced by unbound species,and an apparent increase in fluorescence yield for bound species. Experimental measurements show a nearly a factor of 2 increase in excitation intensity within the nanocavities, and factor of 6 increase in yield. A simple electromangetic model of a dipole within a nanocavity shows an increase in radiative output consistent with our yield estimates and also verifies the strong fluorescence isolation from species lying outside the nanocavity.

Paper Details

Date Published: 31 March 2005
PDF: 8 pages
Proc. SPIE 5703, Plasmonics in Biology and Medicine II, (31 March 2005); doi: 10.1117/12.591666
Show Author Affiliations
Yongdong Liu, Univ. of Utah (United States)
Steve Blair, Univ. of Utah (United States)

Published in SPIE Proceedings Vol. 5703:
Plasmonics in Biology and Medicine II
Tuan Vo-Dinh; Joseph R. Lakowicz; Zygmunt K. Gryczynski, Editor(s)

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