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Proceedings Paper

Drying drops of biological liquids: dynamics of the optical and mechanical properties. Application in rapid medical diagnostics
Author(s): Tatiana A. Yakhno; Anatoly G. Sanin; Vladimir G. Yakhno; Artem S. Pelyushenko; Michael B. Dowell; Christina Vacca; Valentina A. Goutorova
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Paper Abstract

The dynamical characteristics of integral mechanical properties of drying droplets of blood serum, urine and saliva were studied by measuring the acoustic-mechanical impedance (AMI) using a computer-controlled setup described earlier. The method is based on the following idea. When a 5μl liquid drop is drying on the surface of a quartz resonator plate oscillating at a constant frequency (equal to the resonance frequency of an unloaded resonator, 60 kHz), there arises a shear wave highly sensitive to the formation and growth of a new phase at the liquid-quartz interface. The experimental setup measures a change in the complex electric conductivity of the liquid-quartz system, calculates the parameters of the AMI dynamics in the drying drop, and displays their variation on the monitor at the real time scale in the form of a curve. At a time the optical The properties of drying drops were observed. For each disease or a physiological state the geometrical features of the curves were extracted and then the shape indices were calculated. In the cases under study each "pathology" group differed from the "norm" by its specific shape index, by which diseases of other nature did not differ. Possible mechanisms behind formation of the morphological and dynamical differences in drying drops of biological liquids of healthy and sick people are discussed.

Paper Details

Date Published: 1 April 2005
PDF: 11 pages
Proc. SPIE 5692, Advanced Biomedical and Clinical Diagnostic Systems III, (1 April 2005); doi: 10.1117/12.591556
Show Author Affiliations
Tatiana A. Yakhno, Aria Analytics, Inc. (United States)
Institute of Applied Physics RAS (Russia)
Anatoly G. Sanin, Aria Analytics, Inc. (United States)
Institute of Applied Physics RAS (Russia)
Vladimir G. Yakhno, Aria Analytics, Inc. (United States)
Institute of Applied Physics RAS (Russia)
Artem S. Pelyushenko, Institute of Applied Physics RAS (Russia)
Michael B. Dowell, Aria Analytics, Inc. (United States)
5iTech, LLC (United States)
Christina Vacca, Aria Analytics, Inc. (United States)
Valentina A. Goutorova, 5iTech, LLC (United States)

Published in SPIE Proceedings Vol. 5692:
Advanced Biomedical and Clinical Diagnostic Systems III
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron; Gerald E. Cohn, Editor(s)

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