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Proceedings Paper

Novel GMR-based biochip
Author(s): Ting-Chang Lee; Hsin-Chun Huang; Chih-Ming Wang; Che-Lung Hsu; Tsung-Hsun Yang; Jeng-Yang Chang
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Paper Abstract

For the detection of molecular interaction, a novel approach of the guided-mode resonance (GMR) spectroscopy identifies molecules via specific bindings with their ligands immobilized on the grating surface is presented. The structure of GMR device generally consists of two stages -- upper grating layer and waveguide layer. When the wide-band light illuminating, the GMR device inhibits on a specific resonant narrow-band of wavelength, and allows for other wavelength to transmit. The specific resonant narrow-band of wavelength results in the diffraction of the incident wide-band wave and the selection in the waveguide layer. This is very useful in highly sensitive measurement, especially for the variations in the refractive index of bulk media, and for the monitoring of variations in the thickness of thin film. In the simulation, one Si3N4 (n=2) GMR device is designed. When the wavelength of the illumination ranges from 1520nm to 1620nm, the resonant peak wavelength will shift 0.03nm as per 1nm bio-layer (nbio 1.3) has been attached on. Finally, on the basis of the theoretical analysis, the optimization of a spectral GMR sensor in terms of the operation wavelength has been carried out.

Paper Details

Date Published: 7 March 2005
PDF: 8 pages
Proc. SPIE 5702, Optical Diagnostics and Sensing V, (7 March 2005); doi: 10.1117/12.591455
Show Author Affiliations
Ting-Chang Lee, National Central Univ. (Taiwan)
Hsin-Chun Huang, National Central Univ. (Taiwan)
Chih-Ming Wang, National Central Univ. (Taiwan)
Che-Lung Hsu, National Central Univ. (Taiwan)
Tsung-Hsun Yang, National Central Univ. (Taiwan)
Jeng-Yang Chang, National Central Univ. (Taiwan)

Published in SPIE Proceedings Vol. 5702:
Optical Diagnostics and Sensing V
Alexander V. Priezzhev; Gerard L. Cote, Editor(s)

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