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Proceedings Paper

Near-field optical imaging using optically trapped nanoparticles
Author(s): A. R. Faustov; V. I. Shcheslavskiy; G. I. Petrov; V. V. Yakovlev
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Paper Abstract

Our ability to understand the structures and functions of living systems on a cellular and molecular level is mostly determined by the availability of imaging techniques capable of accessing a nanoscopic spatial resolution as well as providing structural information on molecular systems in vivo. While optical methods provide non-invasiveness, their spatial resolution is limited by a fundamental diffraction limit revealed more than 150 years ago by Ernst Abbe. This report addresses this grand-challenge and suggests a novel way of minimally invasive nanoscopic optical imaging inside a living cell. A powerful combination of optical tweezers, nonlinear optics and material science holds a promise of achieving unprecedented resolution of live-cell imaging, which should significantly advance our knowledge of molecular functions on a cellular level.

Paper Details

Date Published: 28 April 2005
PDF: 7 pages
Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); doi: 10.1117/12.591324
Show Author Affiliations
A. R. Faustov, Univ. of Wisconsin/Milwaukee (United States)
V. I. Shcheslavskiy, Univ. of Southampton (United Kingdom)
G. I. Petrov, Univ. of Wisconsin/Milwaukee (United States)
V. V. Yakovlev, Univ. of Wisconsin/Milwaukee (United States)

Published in SPIE Proceedings Vol. 5705:
Nanobiophotonics and Biomedical Applications II
Alexander N. Cartwright; Marek Osinski, Editor(s)

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