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Proceedings Paper

Power and prospects for studying live cells using semiconductor quantum dots
Author(s): Daniele Gerion
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Paper Abstract

The use of quantum dots to study and solve biological issues is bringing scientists and engineers into the realm of pure biology. Yet quantum dots are still a young technology that has not fulfilled all its immense promises. The prospects of using quantum dots in biology motivates a wealth of different studies that include the targeting of organisms in live cells and the characterization of the optical properties of the bioconjugates at the single molecule level. Here, I want to review some experiments using silanized quantum dots. In particular, I want to focus on the versatility of silanized quantum dots for bioconjugation and show how they can be programmed to target the nucleus of live cells. In parallel, silanized qdots are remarkable chromophores that can be used as FRET sensors. FRET efficiencies up to 100% can be reached by tuning the spectral properties of the donor and acceptor pairs.

Paper Details

Date Published: 4 April 2005
PDF: 9 pages
Proc. SPIE 5704, Genetically Engineered and Optical Probes for Biomedical Applications III, (4 April 2005); doi: 10.1117/12.591246
Show Author Affiliations
Daniele Gerion, Lawrence Livermore National Lab. (United States)

Published in SPIE Proceedings Vol. 5704:
Genetically Engineered and Optical Probes for Biomedical Applications III
Darryl J. Bornhop; Samuel I. Achilefu; Ramesh Raghavachari; Alexander P. Savitsky, Editor(s)

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