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Proceedings Paper

Surface-enhanced Raman spectroscopic detection of cancer biomarkers in intact cellular specimens
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Paper Abstract

We have developed a system for the direct spectroscopic identification of protein biomarkers in biological samples. By conjugating Raman dyes and biomolecular targeting agents to gold nanoparticles, we have produced highly selective optically encoded probes. The nanostructures are grown within a cellular sample to generate a surface that is highly active for surface enhanced Raman spectroscopy (SERS). Both in vitro characterizations of SERS detection as well as the sensitive and specific detection of cancer biomarkers in cultured cancer cells have been demonstrated.

Paper Details

Date Published: 29 March 2005
PDF: 9 pages
Proc. SPIE 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III, (29 March 2005); doi: 10.1117/12.591178
Show Author Affiliations
Dominic Omar Ansari, Georgia Institute of Technology (United States)
Emory Univ. (United States)
Douglas A. Stuart, Northwestern Univ. (United States)
Shuming Nie, Georgia Institute of Technology (United States)
Emory Univ. (United States)


Published in SPIE Proceedings Vol. 5699:
Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III
Dan V. Nicolau; Dan V. Nicolau; Jörg Enderlein; Ramesh Raghavachari; Robert C. Leif; Daniel L. Farkas, Editor(s)

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