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Proceedings Paper

Thermal fixation: a central outcome of hyperthermic therapies (Invited Paper)
Author(s): James E. Coad
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Paper Abstract

Currently, several minimally invasive hyperthermic-based surgical technologies are available for the treatment of dysfunctional and neoplastic tissues in a variety of organ systems. These therapies involve a number of different modalities for delivering heat energy to the target tissue, including radiofrequency/microwave, conductive/convective, loop resection, and others. Despite differences in energy transfer and organ system treated, hyperthermic lesions often have a multiregional architecture with a central thermal fixation region, adjacent middle coagulative-type necrosis region, and outer transitional region of variable cell injury/death. The regional percentages of these components vary depending on the overall thermal history distribution across the lesion. The thermal-fixed region generally lacks a wound healing response, resists breakdown/tissue repair, and may elicit a localized foreign body-type reaction. The other two regions generally undergo wound healing/repair with scar formation. The features of thermal fixation are highlighted and explored through several histopathologic case vignettes.

Paper Details

Date Published: 14 April 2005
PDF: 8 pages
Proc. SPIE 5698, Thermal Treatment of Tissue: Energy Delivery and Assessment III, (14 April 2005); doi: 10.1117/12.591175
Show Author Affiliations
James E. Coad, West Virginia Univ. (United States)


Published in SPIE Proceedings Vol. 5698:
Thermal Treatment of Tissue: Energy Delivery and Assessment III
Thomas P. Ryan, Editor(s)

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