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Proceedings Paper

Frequency domain tomography in small animals with the equation of radiative transfer
Author(s): Kui Ren; Bryte Moa-Anderson; Guillaume Bal; Xuejun Gu; Andreas H. Hielscher
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Paper Abstract

We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.

Paper Details

Date Published: 28 April 2005
PDF: 10 pages
Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.591113
Show Author Affiliations
Kui Ren, Columbia Univ. (United States)
Bryte Moa-Anderson, Columbia Univ. (United States)
Guillaume Bal, Columbia Univ. (United States)
Xuejun Gu, Columbia Univ. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 5693:
Optical Tomography and Spectroscopy of Tissue VI
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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