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Proceedings Paper

Combined optical tomographic and magnetic resonance imaging of tumor bearing mice
Author(s): J. Masciotti; G. Abdoulaev; J. Hur; J. Papa; J. Bae; J. Huang; D. Yamashiro; J. Kandel; A. H. Hielscher
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Paper Abstract

With the advent of small animal imaging systems, it has become possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images as well as studying cerebral blood volume (CBV), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2). Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution and insensitive to CBF, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and CBV with high temporal resolution. In this study we present our first results concerning coregistration of MRI and optical data. By applying both modalities to imaging of kidney tumors in mice that undergo VEGF treatment, we illustrate how these imaging modalities can supplement each other and cross validation can be performed.

Paper Details

Date Published: 28 April 2005
PDF: 8 pages
Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.590844
Show Author Affiliations
J. Masciotti, Columbia Univ. (United States)
G. Abdoulaev, Columbia Univ. (United States)
J. Hur, Columbia Univ. (United States)
J. Papa, Columbia Univ. (United States)
J. Bae, Columbia Univ. (United States)
J. Huang, Columbia Univ. (United States)
D. Yamashiro, Columbia Univ. (United States)
J. Kandel, Columbia Univ. (United States)
A. H. Hielscher, Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 5693:
Optical Tomography and Spectroscopy of Tissue VI
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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