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Proceedings Paper

Functionalized luminescent oxide nanoparticles for sodium channel imaging at the single molecule level
Author(s): E. Beaurepaire; D. Giaume; V. Buissette; M.-P. Sauviat; D. Casanova; E. Auksorius; J.-L. Martin; K. Lahlil; T. Gacoin; J.-P. Boilot; A. Alexandrou
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Paper Abstract

Lanthanide-ion doped oxide nanoparticles were functionalized for use as fluorescent biological labels. These nanoparticles are synthesized directly in water which facilitates their functionalization, and are very photostable without emission intermittency. Nanoparticles functionalized with guanidinium groups act as artificial toxins and specifically target sodium channels. They are individually detectable in cardiac myocytes, revealing a heterogeneous distribution of sodium channels. Functionalized oxide nanoparticles appear as a novel tool particularly well adapted to long-term single-molecule tracking.

Paper Details

Date Published: 28 April 2005
PDF: 7 pages
Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); doi: 10.1117/12.590737
Show Author Affiliations
E. Beaurepaire, Lab. for Optics and Biosciences, CNRS-INSERM, Ecole Polytechnique (France)
D. Giaume, Lab. of Condensed Matter Physics, CNRS, Ecole Polytechnique (France)
V. Buissette, Lab. of Condensed Matter Physics, CNRS, Ecole Polytechnique (France)
M.-P. Sauviat, Lab. for Optics and Biosciences, CNRS-INSERM, Ecole Polytechnique (France)
D. Casanova, Lab. for Optics and Biosciences, CNRS-INSERM, Ecole Polytechnique (France)
E. Auksorius, Lab. for Optics and Biosciences, CNRS-INSERM, Ecole Polytechnique (France)
J.-L. Martin, Lab. for Optics and Biosciences, CNRS-INSERM, Ecole Polytechnique (France)
K. Lahlil, Lab. of Condensed Matter Physics, CNRS, Ecole Polytechnique (France)
T. Gacoin, Lab. of Condensed Matter Physics, CNRS, Ecole Polytechnique (France)
J.-P. Boilot, Lab. of Condensed Matter Physics, CNRS, Ecole Polytechnique (France)
A. Alexandrou, Lab. for Optics and Biosciences, CNRS-INSERM, Ecole Polytechnique (France)


Published in SPIE Proceedings Vol. 5705:
Nanobiophotonics and Biomedical Applications II
Alexander N. Cartwright; Marek Osinski, Editor(s)

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