Share Email Print
cover

Proceedings Paper

Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 μm-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.

Paper Details

Date Published: 13 April 2005
PDF: 4 pages
Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.590534
Show Author Affiliations
Kirill V. Larin, The Univ. of Texas Medical Branch at Galveston (United States)
Univ. of Houston (United States)
Rinat O. Esenaliev, The Univ. of Texas Medical Branch at Galveston (United States)
Eunha Kim, The Univ. of Texas at Austin (United States)
Sanghoon Oh, The Univ. of Texas at Austin (United States)
Massoud Motamedi, The Univ. of Texas Medical Branch at Galveston (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 5690:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

© SPIE. Terms of Use
Back to Top