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Proceedings Paper

Experimental and theoretical study of the THz absorption spectra of selected tripeptides
Author(s): Frank Rutz; R. Wilk; T. Kleine-Ostmann; J. Grunenberg; Martin Koch
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Paper Abstract

We investigate small peptides using standard terahertz (THz) time-domain spectroscopy. As a test set we examine the tripeptides glutathione, gly-gly-gly and enalapril maleate at room temperature. While earlier investigations of short-chain polypeptides with a conventional FTIR spectrometer were performed at higher THz frequencies, we present first measurements between 150 GHz and 2 THz and compare our measurements to density functional theory (DFT) calculations in order to assign the measured resonances to distinct molecular motions. DFT calculations obtained for a single molecule (glutathione), dimers (gly-gly-gly) and ion pairs (enalapril maleate) coupled via H-bonds, reproduce correctly the number of resonances observed in the experiment.

Paper Details

Date Published: 25 March 2005
PDF: 8 pages
Proc. SPIE 5727, Terahertz and Gigahertz Electronics and Photonics IV, (25 March 2005); doi: 10.1117/12.590532
Show Author Affiliations
Frank Rutz, Institut for Hochfrequenztechnik (Germany)
R. Wilk, Institut for Hochfrequenztechnik (Germany)
T. Kleine-Ostmann, Institut for Hochfrequenztechnik (Germany)
J. Grunenberg, Institut for Organische Chemie (Germany)
Martin Koch, Institut for Hochfrequenztechnik (Germany)

Published in SPIE Proceedings Vol. 5727:
Terahertz and Gigahertz Electronics and Photonics IV
R. Jennifer Hwu; Kurt J. Linden, Editor(s)

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