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Proceedings Paper

Metal nanoparticles as passive and active tools for bioanalytics
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Paper Abstract

Metal nanoparticles represent an interesting tool for bioanalytics. Due to their small size, attachment to biomolecules does not interfere significantly with specific molecular binding. Therefore particles can be applied as label in affinity assays (e.g., DNA hybridization), using setups with high parallelization. Beside this rather passive use of nanoparticles, these structures can also be utilized as 'nano antenna' for the conversion of laser light pulses into heat. Using DNA-modified particles sequence-specific bound to DNA, a novel restriction technique is in development that applies this conversion for local DNA destruction. Metal nanoparticles combine the ability for highly precise positioning (due to specific molecular binding) with the possibility of optical access in a bright-field mode. They exhibit an interesting potential for spanning the gap between the macroscopic technical environment and the molecular scale, thereby enabling a true integration of nanoscale constructs with today’s technology.

Paper Details

Date Published: 29 March 2005
PDF: 5 pages
Proc. SPIE 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III, (29 March 2005); doi: 10.1117/12.590501
Show Author Affiliations
Wolfgang Fritzsche, Institute for Physical High Technology (Germany)
Andrea Csaki, Institute for Physical High Technology (Germany)
Andrea Steinbrueck, Institute for Physical High Technology (Germany)
Frank Garwe, JenLab GmbH (Germany)
Karsten Koenig, JenLab GmbH (Germany)
Markus Raschke, Max-Born-Institute (Germany)


Published in SPIE Proceedings Vol. 5699:
Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III
Dan V. Nicolau; Dan V. Nicolau; Jörg Enderlein; Ramesh Raghavachari; Robert C. Leif; Daniel L. Farkas, Editor(s)

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