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Proceedings Paper

Correlation of collagen synthesis with polarization-sensitive optical coherence tomography imaging of in vitro human atherosclerosis
Author(s): Wen-Chuan Kuo; Jeou-Jong Shyu; Nai-Kuan Chou; Chih-Ming Lai; En-Kuang Tien; Huan-Jang Huang; Chien Chou; Gwo-Jen Jan
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Paper Abstract

Atherosclerosis is unquestionably the leading cause of morbidity and mortality in developed countries. In the mean time, the worldwide importance of acute vascular syndromes is increasing. Because collagen fiber is a critical component of atherosclerotic lesions; it constitutes up to 60% of the total atherosclerotic plaque protein. The uncontrolled collagen accumulation leads to arterial stenosis, whereas excessive collagen breakdown weakens plaques thereby making them prone to rupture finally. Thus, in this study, we present the first application, to our knowledge, of using polarization-sensitive optical coherence tomography (PS-OCT) in human atherosclerosis. We demonstrate this technique for imaging of intensity, birefringence, and fast-axis orientation simultaneously in atherosclerotic plaques. This in vitro study suggests that the birefringence change in plaque is due to the prominent deposition of collagen according to the correlation of PS-OCT images with histological counterpart. Moreover, we can acquire quantitative criteria based on the change of polarization of incident beam to estimate whether the collagen synthesized is "too much" or "not enough". Thus by combining of high resolution intensity imaging and birefringence detection makes PS-OCT could be a potentially powerful tool for early assessment of atherosclerosis appearance and the prediction of plaque rupture in clinic.

Paper Details

Date Published: 13 April 2005
PDF: 9 pages
Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.590220
Show Author Affiliations
Wen-Chuan Kuo, National Taiwan Univ. (Taiwan)
Jeou-Jong Shyu, National Taiwan Univ. (Taiwan)
Nai-Kuan Chou, National Taiwan Univ. Hospital (Taiwan)
Chih-Ming Lai, Ming Chuan Univ. (Taiwan)
En-Kuang Tien, National Taiwan Univ. (Taiwan)
Huan-Jang Huang, National Yang-Ming Univ. (Taiwan)
Chien Chou, National Yang-Ming Univ. (Taiwan)
Gwo-Jen Jan, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 5690:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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