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Proceedings Paper

Endoscopic imaging of the human vocal cords using polarization-sensitive optical coherence tomography
Author(s): Mark C. Pierce; Adam Klein; James A. Burns; Milen Shishkov; B. Hyle Park; Guillermo J. Tearney; Brett E. Bouma; Steven M. Zeitels; Johannes F. de Boer
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Paper Abstract

Endoscopic polarization-sensitive optical coherence tomography (PS-OCT) was used to obtain cross-sectional images of laryngeal tissues in human subjects, in vivo. Imaging in tissue to a depth of 1.2 mm and with axial resolution below 10 micrometers enabled the epithelial layer to be readily identified in OCT intensity images, with the underlying superficial lamina propria characterized by an increased backscatter signal, and increased birefringence in polarization-sensitive images.

Paper Details

Date Published: 25 April 2005
PDF: 3 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.589870
Show Author Affiliations
Mark C. Pierce, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Adam Klein, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
James A. Burns, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Milen Shishkov, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
B. Hyle Park, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Guillermo J. Tearney, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Brett E. Bouma, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Steven M. Zeitels, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Johannes F. de Boer, Wellman Ctr. for Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong; Eugene A. Trowers; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Reza S. Malek; Henry Hirschberg; Kenneth Eugene Bartels; Steen J. Madsen; Lloyd P. Tate; Lawrence S. Bass; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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