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Proceedings Paper

Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography
Author(s): Mark C. Pierce; Chulmin Joo; Barry Cense; Eli Weinberg; Boris Hyle Park; Mircea Mujat; Jeffrey Borenstein; Guillermo J. Tearney; Brett E. Bouma; Johannes F de Boer
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Paper Abstract

Microfluidic devices are becoming increasingly popular for many applications, enabling biological and chemical reactions to be performed with nano- and picoliter sample volumes. Accurate measurement and monitoring of fluid flow behavior in the small channels of microfluidic systems is important for evaluating the performance of existing devices, and in the modeling and design of new microfluidic networks. We present here the results of experiments using spectral-domain optical Doppler tomography (SD-ODT) to measure fluid flow in single-layer microfluidic devices. The principles behind flow imaging with SD-ODT are reviewed, a method for velocity calibration is described, and cross-sectional and en-face images of fluid velocity in microfluidic channels are presented.

Paper Details

Date Published: 1 April 2005
PDF: 5 pages
Proc. SPIE 5692, Advanced Biomedical and Clinical Diagnostic Systems III, (1 April 2005); doi: 10.1117/12.589862
Show Author Affiliations
Mark C. Pierce, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Chulmin Joo, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Barry Cense, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Eli Weinberg, Charles Stark Draper Lab. (United States)
Boris Hyle Park, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Mircea Mujat, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Jeffrey Borenstein, Charles Stark Draper Lab. (United States)
Guillermo J. Tearney, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Brett E. Bouma, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Johannes F de Boer, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 5692:
Advanced Biomedical and Clinical Diagnostic Systems III
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron; Gerald E. Cohn, Editor(s)

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