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Proceedings Paper

Techniques for delivery and monitoring of TOOKAD(WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities
Author(s): Robert A. Weersink; Arjen Bogaards; Mark Gertner; Sean R.H. Davidson; Kai Zhang; George Netchev; John Trachtenberg; Brian C. Wilson
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Paper Abstract

Photodynamic therapy of solid organs requires sufficient PDT dose throughout the target tissue while minimizing the dose to proximal normal structures. This requires treatment planning for position and power of the multiple delivery channels, complemented by on-line monitoring during treatment of light delivery, drug concentration and oxygen levels. We describe our experience in implementing this approach in Phase I/II clinical trials of the Pd-bacteriophephorbide photosensitizer TOOKAD (WST09)-mediated PDT of recurrent prostate cancer following radiation failure. We present several techniques for delivery and monitoring of photodynamic therapy, including beam splitters for light delivery to multiple delivery fibers, multi-channel light dosimetry devices for monitoring the fluence rate in the prostate and surrounding organs, methods of measuring the tissue optical properties in situ, and optical spectroscopy for monitoring drug pharmacokinetics of TOOKAD in whole blood samples and in situ in the prostate. Since TOOKAD is a vascular-targeted agent, the design and implementation of the techniques are different than for cellular-targeted agents. Further development of these delivery and monitoring techniques will permit full on-line monitoring of the treatment that will enable real-time, patient-specific and optimized delivery of PDT.

Paper Details

Date Published: 8 April 2005
PDF: 11 pages
Proc. SPIE 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV, (8 April 2005); doi: 10.1117/12.589700
Show Author Affiliations
Robert A. Weersink, Lab. for Applied Biophotonics, Univ. Health Network (Canada)
Arjen Bogaards, Ontario Cancer Institute/Univ. of Toronto (Canada)
Mark Gertner, Ontario Cancer Institute/Univ. of Toronto (Canada)
Sean R.H. Davidson, Ontario Cancer Institute/Univ. of Toronto (Canada)
Kai Zhang, Lab. for Applied Biophotonics, Univ. Health Network (Canada)
George Netchev, Lab. for Applied Biophotonics, Univ. Health Network (Canada)
John Trachtenberg, Princess Margaret Hospital/Univ. of Toronto (Canada)
Brian C. Wilson, Laboratory for Applied Biophotonics (Canada)
Ontario Cancer Institute/Univ. of Toronto (Canada)


Published in SPIE Proceedings Vol. 5689:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV
David Kessel, Editor(s)

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