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Proceedings Paper

Photoacoustic tomography and molecular fluorescence imaging: dual modality imaging of small animal brains in vivo
Author(s): Xueyi Xie; Jung-Taek Oh; Meng-Lin Li; Geng Ku; Xueding Wang; Shi Ke; Chun Li; Sergiu Similache; George Stoica; Lihong V. Wang
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Paper Abstract

We present a dual modality imaging technique by combining photoacoustic tomography (PAT) and near-infrared (NIR) fluorescence imaging for the study of animal model tumors. PAT provides high-resolution structural images of tumor angiogenesis, and fluorescence imaging offers high sensitivity to molecular probes for tumor detection. Coregistration of the PAT and fluorescence images was performed on nude mice with M21 human melanoma cell lines with αvβ3 integrin expression. An integrin αvβ3-targeted peptide-ICG conjugated NIR fluorescent contrast agent was used as the molecular probe for tumor detection. PAT was employed to noninvasively image the brain structures and the angiogenesis associated with tumors in nude mice. Coregistration of the PAT and fluorescence images was used in this study to visualize tumor location, angiogenesis, and brain structure simultaneously.

Paper Details

Date Published: 25 April 2005
PDF: 4 pages
Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); doi: 10.1117/12.589670
Show Author Affiliations
Xueyi Xie, Texas A&M Univ. (United States)
Jung-Taek Oh, Texas A&M Univ. (United States)
Meng-Lin Li, Texas A&M Univ. (United States)
Geng Ku, Texas A&M Univ. (United States)
Xueding Wang, Texas A&M Univ. (United States)
Shi Ke, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Chun Li, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Sergiu Similache, Texas A&M Univ. (United States)
George Stoica, Texas A&M Univ. (United States)
Lihong V. Wang, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 5697:
Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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