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Proceedings Paper

Characterization of plasmon-resonant gold nanorods as near-infrared optical contrast agents investigated using a double-integrating sphere system
Author(s): Amy Oldenburg; Daniel A. Zweifel; Chenyang Xu; Alexander Wei; Stephen A. Boppart
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Paper Abstract

The potential for using plasmon-resonant gold nanorods as targeted contrast agents for in vivo coherent optical imaging is investigated. Separation of the relative strengths of light scattering and absorption of plasmon-resonant nanorods are measured with a double-integrating sphere system at 774 and 1304nm. The maximum likelihood ratio is then used to test the statistical significance of optical changes observed after application of contrast agents to tissue phantoms. Gold plasmon-resonant nanorods with a longitudinal resonance near 800nm are imaged within varying concentrations of intralipid using a 101dB sensitivity, 800nm optical coherence tomography (OCT) system. We estimate the minimum OCT detectible concentration of these nanorods (ca. 15 by 45nm) within 1.1% intralipid to be 25microg/mL of gold.

Paper Details

Date Published: 31 March 2005
PDF: 11 pages
Proc. SPIE 5703, Plasmonics in Biology and Medicine II, (31 March 2005); doi: 10.1117/12.589617
Show Author Affiliations
Amy Oldenburg, Beckman Institute/Univ. of Illinois at Urbana-Champaign (United States)
Daniel A. Zweifel, Purdue Univ. (United States)
Chenyang Xu, Beckman Institute/Univ. of Illinois at Urbana-Champaign (United States)
Alexander Wei, Purdue Univ. (United States)
Stephen A. Boppart, Beckman Institute/Univ. of Illinois at Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 5703:
Plasmonics in Biology and Medicine II
Tuan Vo-Dinh; Joseph R. Lakowicz; Zygmunt K. Gryczynski, Editor(s)

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