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Proceedings Paper

Enhancing the photoluminescence of peptide-coated nanocrystals
Author(s): James M. Tsay; Soeren Doose; Fabien Pinaud; Shimon Weiss
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Paper Abstract

Colloidal NCs consist of an inorganic particle and an organic coating that determines their solubility, functionality, and influences their photophysics. In order for these NCs to be biocompatible, they must be water-soluble, nontoxic to the cell, and offer conjugation chemistries for attaching recognition molecules to their surfaces. In addition they should efficiently target to biomolecules of interest, be chemically stable, and preserve their high photostability. The requirements for their application in single-molecule biological studies are even more stringent: fluorescent NCs should be monodisperse, have relatively small size (to limit steric hindrance), reduced blinking, large saturation intensity, and high quantum yield (QY).

Paper Details

Date Published: 28 April 2005
PDF: 9 pages
Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); doi: 10.1117/12.589458
Show Author Affiliations
James M. Tsay, Univ. of California/Los Angeles (United States)
Soeren Doose, Univ. of California/Los Angeles (United States)
Fabien Pinaud, Univ. of California/Los Angeles (United States)
Shimon Weiss, Univ. of California/Los Angeles (United States)


Published in SPIE Proceedings Vol. 5705:
Nanobiophotonics and Biomedical Applications II
Alexander N. Cartwright; Marek Osinski, Editor(s)

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