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Proceedings Paper

Near-infrared Raman spectroscopy to detect the calcification of the annular mitral valve
Author(s): Rick Rocha; E. P.U. Otero; M. S. Costa; Antonio Guillermo Jose Balbin Villaverde; P. M.A. Pomerarantzeff; Marcos T. Tavares Pacheco
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Paper Abstract

Cardiac valves are subjected to high repetitive mechanical stresses, particularly at the hinge points of the cusps and leaflets due to the over 40 millions cardiac cycles per year. These delicate structures can suffer cumulative lesions, complicated by the deposition of calcium phosphate mineral, which may lead to clinically important disease. Near Infrared Raman Spectroscopy gives important information about biological tissues composition and it is being used for diagnosis of some pathologies. The aim of this work was to detect trough the use of the Raman Spectroscopy technique the mitral annular calcification. A Ti:sapphire laser operating at the near infrared wavelength of 785 nm was used for the excitation of the valve samples and the Raman radiation was detected by an optical spectrometer with a CCD liquid nitrogen cooled detector. In all, ten samples of normal and pathologic tissues were studied. They were approximately squared with the lateral size of 5 mm. It was observed that the Raman spectrum of the calcified mitral valve showed different behavior, when compared to normal tissues. Results indicate that this technique could be used to detect the deposition of the calcium phosphate mineral over the mitral valve.

Paper Details

Date Published: 21 October 2004
PDF: 5 pages
Proc. SPIE 5622, 5th Iberoamerican Meeting on Optics and 8th Latin American Meeting on Optics, Lasers, and Their Applications, (21 October 2004); doi: 10.1117/12.589448
Show Author Affiliations
Rick Rocha, Univ. do Vale do Paraiba (Brazil)
E. P.U. Otero, Univ. Estadual de Campinas (Brazil)
M. S. Costa, Univ. do Vale do Paraiba (Brazil)
Antonio Guillermo Jose Balbin Villaverde, Univ. do Vale do Paraiba (Brazil)
P. M.A. Pomerarantzeff, Univ. de Sao Paulo (Brazil)
Marcos T. Tavares Pacheco, Univ. do Vale do Paraiba (Brazil)

Published in SPIE Proceedings Vol. 5622:
5th Iberoamerican Meeting on Optics and 8th Latin American Meeting on Optics, Lasers, and Their Applications
Aristides Marcano O.; Jose Luis Paz, Editor(s)

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