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Proceedings Paper

Cytotoxicity of the photoproducts of Photogem after photobleaching induced by intense illumination
Author(s): Priscila F.C. Menezes; Hidetake Imasato; Janice R. Perussi; Claudia Adriana Sousa Melo; Vanderlei Salvador Bagnato
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Paper Abstract

Porphyrins can be degraded by light. Photogem is a photosensitizer used in PDT in Brazil. Photogem irradiation at 514 and 630 nm change its fluorescence and absorption due to photodegradation and photoproducts formation (new absorption band in 640 nm). Irradiated Photogem was incubated with tumor or non-tumor cells. The low toxicity suggests that the photoproducts of Photogem are less cytotoxic than the original formulation.

Paper Details

Date Published: 21 October 2004
PDF: 5 pages
Proc. SPIE 5622, 5th Iberoamerican Meeting on Optics and 8th Latin American Meeting on Optics, Lasers, and Their Applications, (21 October 2004); doi: 10.1117/12.589417
Show Author Affiliations
Priscila F.C. Menezes, Univ. de Sao Paolo (Brazil)
Hidetake Imasato, Univ. de Sao Paulo (Brazil)
Janice R. Perussi, Univ. de Sao Paulo (Brazil)
Claudia Adriana Sousa Melo, Univ. de Sao Paulo (Brazil)
Vanderlei Salvador Bagnato, Univ. de Sao Paulo (Brazil)


Published in SPIE Proceedings Vol. 5622:
5th Iberoamerican Meeting on Optics and 8th Latin American Meeting on Optics, Lasers, and Their Applications
Aristides Marcano O.; Jose Luis Paz, Editor(s)

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