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Proceedings Paper

In vivo imaging polarimeter for oral precancer detection
Author(s): Jungrae Chung; Woonggyu Jung; Petra Wilder-Smith; Zhongping Chen
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Paper Abstract

The Mueller matrix describes all the polarizing properties of a sample, and therefore the optical differences between non-cancerous and pre-cancerous tissue should be present within the matrix elements. We present in this paper that a high speedpolarimetry system generates 16 full Mueller matrices to characterize tissues. Feature extraction is done on the Mueller matrix elements resulting in the depolarizance and retardance images by polar decomposition to detect and classify of early oral cancers and pre-cancerous changes in epithelium, such as dysplasia. These images are compared with orthogonal polarization image and analyzed in an attempt to determine the important factors for the identification of cancerous lesions from their benign counterparts. Our results indicate that polarimetry has potential as a method for the in vivo early detection and diagnosis of oral premalignancy and malignancy.

Paper Details

Date Published: 28 April 2005
PDF: 16 pages
Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.589401
Show Author Affiliations
Jungrae Chung, Beckman Laser Institute, Univ. of California/Irvine (United States)
Woonggyu Jung, Beckman Laser Institute, Univ. of California/Irvine (United States)
Univ. of California/Irvine (United States)
Petra Wilder-Smith, Beckman Laser Institute, Univ. of California/Irvine (United States)
Zhongping Chen, Beckman Laser Institute, Univ. of California/Irvine (United States)
Univ. of California/Irvine (United States)


Published in SPIE Proceedings Vol. 5693:
Optical Tomography and Spectroscopy of Tissue VI
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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