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Proceedings Paper

Diode laser monitor for singlet molecular oxygen
Author(s): Seonkyung Lee; Leyun Zhu; Ahmed Minhaj; Michael F. Hinds; A. A. Ferrante; D. H. Vu; David Rosen; Steven J. Davis; Tayyaba Hasan
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Paper Abstract

Monitoring singlet molecular oxygen (1O2) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet oxygen monitor based on a pulsed diode laser technology. In this paper, we present results of singlet oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet oxygen monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.

Paper Details

Date Published: 8 April 2005
PDF: 7 pages
Proc. SPIE 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV, (8 April 2005); doi: 10.1117/12.589347
Show Author Affiliations
Seonkyung Lee, Physical Sciences Inc. (United States)
Leyun Zhu, Physical Sciences Inc. (United States)
Ahmed Minhaj, Physical Sciences Inc. (United States)
Michael F. Hinds, Physical Sciences Inc. (United States)
A. A. Ferrante, Physical Sciences Inc. (United States)
D. H. Vu, Physical Sciences Inc. (United States)
David Rosen, Physical Sciences,Inc. (United States)
Steven J. Davis, Physical Sciences Inc. (United States)
Tayyaba Hasan, Massachusetts General Hospital, Wellman Labs. of Photomedicine (United States)


Published in SPIE Proceedings Vol. 5689:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV
David Kessel, Editor(s)

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