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Proceedings Paper

Deep penetrating photoacoustic tomography in biological tissues
Author(s): Geng Ku; Xueding Wang; Xueyi Xie; George Stoica; Lihong V. Wang
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Paper Abstract

Photoacoustic tomography (PAT) in a circular scanning configuration was developed to image the deeply embedded optical heterogeneity in biological tissues. Based on the intrinsic contrast between blood and chicken breast muscle, an embedded blood object that was 5 cm deep in the tissue was detected using pulsed laser light at a wavelength of 1064 nm. Compared with detectors for flat active surfaces, cylindrically focused ultrasonic transducers can reduce the interference generated from the off-plane photoacoustic sources and make the image in the scanning plane clearer. While the optical penetration was optimized with near-infrared laser pulses of 800 nm in wavelength, the optical contrast was enhanced by indocyanine green (ICG) whose absorption peak matched the laser wavelength. This optimized PAT was able to image fine objects embedded at a depth of up to 5.2-cm, which is 6.2 times the 1/e optical penetration depth, in chicken breast muscle, at a resolution of < ~750 microns with a sensitivity of <7 pmol of ICG in blood. The resolution was found to deteriorate slowly with increasing imaging depth.

Paper Details

Date Published: 25 April 2005
PDF: 10 pages
Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); doi: 10.1117/12.588798
Show Author Affiliations
Geng Ku, Texas A&M Univ. (United States)
Xueding Wang, Texas A&M Univ. (United States)
Xueyi Xie, Texas A&M Univ. (United States)
George Stoica, Texas A&M Univ. (United States)
Lihong V. Wang, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 5697:
Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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