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Proceedings Paper

Tissue temperature monitoring during interstitial photodynamic therapy
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Paper Abstract

During δ-aminolevulinic acid (ALA) based Interstitial Photodynamic Therapy (IPDT) a high light fluence rate is present close to the source fibers. This might induce an unintentional tissue temperature increase of importance for the treatment outcome. In a previous study, we have observed, that the absorption in the tissue increases during the treatment. A system to measure the local tissue temperature at the source fibers during IPDT on tissue phantoms is presented. The temperature was measured by acquiring the fluorescence from small Cr3+-doped crystals attached to the tip of the illumination fiber used in an IPDT-system. The fluorescence of the Alexandrite crystal used is temperature dependent. A ratio of the intensity of the fluorescence was formed between two different wavelength bands in the red region. The system was calibrated by immersing the fibers in an Intralipid solution placed in a temperature controlled oven. Measurements were then performed by placing the fibers interstitially in a pork chop as a tissue phantom. Measurements were also performed superficially on skin on a volunteer. A treatment was conducted for 10 minutes, and the fluorescence was measured each minute during the illumination. The fluorescence yielded the temperature at the fiber tip through the calibration curve. The measurements indicate a temperature increase of a few degrees during the simulated treatment.

Paper Details

Date Published: 14 April 2005
PDF: 11 pages
Proc. SPIE 5698, Thermal Treatment of Tissue: Energy Delivery and Assessment III, (14 April 2005); doi: 10.1117/12.588485
Show Author Affiliations
Jenny Svensson, Lund Institute of Technology (Sweden)
Ann Johansson, Lund Institute of Technology (Sweden)
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)

Published in SPIE Proceedings Vol. 5698:
Thermal Treatment of Tissue: Energy Delivery and Assessment III
Thomas P. Ryan, Editor(s)

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