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Proceedings Paper

Simultaneous diffuse near-infrared imaging of hemodynamic and oxygenation changes and electroencephalographic measurements of neuronal activity in the human brain
Author(s): Tommi Noponen; Dubravko Kicic; Kalle Kotilahti; Timo Kajava; Seppo Kahkonen; Ilkka Nissila; Pekka Merilainen; Toivo Katila
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Paper Abstract

Visually evoked hemodynamic responses and potentials were simultaneously measured using a 16-channel optical imaging instrument and a 60-channel electroencephalography instrument during normo-, hypo- and hypercapnia from three subjects. Flashing and pattern-reversed checkerboard stimuli were used. The study protocol included two counterbalanced measurements during both normo- and hypocapnia and normo- and hypercapnia. Hypocapnia was produced by controlled hyperventilation and hypercapnia by breathing carbon dioxide enriched air. Near-infrared imaging was also used to monitor the concentration changes of oxy- and deoxyhaemoglobin due to hypo- and hypercapnia. Hemodynamic responses and evoked potentials were successfully detected for each subject above the visual cortex. The latencies of the hemodynamic responses during hypocapnia were shorter whereas during hypercapnia they were longer when compared to the latencies during normocapnia. Hypocapnia tended to decrease the latencies of visually evoked potentials compared to those during normocapnia while hypercapnia did not show any consistent effect to the potentials. The developed measurement setup and the study protocol provide the opportunity to investigate the neurovascular coupling and the links between the baseline level of blood flow, electrical activity and hemodynamic responses in the human brain.

Paper Details

Date Published: 28 April 2005
PDF: 12 pages
Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.588207
Show Author Affiliations
Tommi Noponen, Helsinki Univ. of Technology (Finland)
Helsinki Univ. (Finland)
Helsinki Univ. Central Hospital (Finland)
Dubravko Kicic, Helsinki Univ. (Finland)
Helsinki Univ. Central Hospital (Finland)
Kalle Kotilahti, Helsinki Univ. of Technology (Finland)
Helsinki Univ. (Finland)
Helsinki Univ. Central Hospital (Finland)
Timo Kajava, Helsinki Univ. of Technology (Finland)
Seppo Kahkonen, Helsinki Univ. Central Hospital (Finland)
Helsinki Univ. (Finland)
Ilkka Nissila, Helsinki Univ. of Technology (Finland)
Helsinki Univ. (Finland)
Helsinki Univ. Central Hospital (Finland)
Pekka Merilainen, Helsinki Univ. of Technology (Finland)
Helsinki Univ. (Finland)
Toivo Katila, Helsinki Univ. of Technology (Finland)
Helsinki Univ. (Finland)
Helsinki Univ. Central Hospital (Finland)


Published in SPIE Proceedings Vol. 5693:
Optical Tomography and Spectroscopy of Tissue VI
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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