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Proceedings Paper

Pulse modulation image sensors for on-chip bioimaging and biosensing applications
Author(s): Takashi Tokuda; David C. Ng; Hideki Okamoto; Keiichiro Kagawa; Jun Ohta; Masahiro Nunoshita
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Paper Abstract

Image sensors with pulse modulation measurement scheme are fabricated for bioimaging and biosensing ap-plications. We designed pulse modulation photosensors, a 64×64-pixels image sensor for in vitro bioimaging, and a 176×144-pixels (QCIF) image sensor for in vivo bioimaging. We demonstrated the feasibility of the pulse modulation measurement scheme for biosensing applications. We obtained a dynamic range of 120dB and minimum sensing intensity level of 2nW/cm2. We also confirmed that 0.2% of intensity change is detectable at the minimum intensity region. An in vitro, on-chip imaging of a mouse hippocampus was successfully demonstrated. A sensor module for in vivo imaging is also developed.

Paper Details

Date Published: 7 March 2005
PDF: 7 pages
Proc. SPIE 5677, Sensors and Camera Systems for Scientific and Industrial Applications VI, (7 March 2005); doi: 10.1117/12.588168
Show Author Affiliations
Takashi Tokuda, Nara Institute of Science and Technology (Japan)
David C. Ng, Nara Institute of Science and Technology (Japan)
Hideki Okamoto, Nara Institute of Science and Technology (Japan)
Keiichiro Kagawa, Nara Institute of Science and Technology (Japan)
Jun Ohta, Nara Institute of Science and Technology (Japan)
Masahiro Nunoshita, Nara Institute of Science and Technology (Japan)


Published in SPIE Proceedings Vol. 5677:
Sensors and Camera Systems for Scientific and Industrial Applications VI
Morley M. Blouke, Editor(s)

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