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Proceedings Paper

Percutaneous MRI-guided laser thermal therapy in canine prostate
Author(s): Roger J. McNichols; Ashok Gowda; Marc D. Gelnett; Roger J. Stafford
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Paper Abstract

Prostate cancer is the most common cancer in American men excluding skin cancer, and approximately 230,000 cases of prostate cancer will be diagnosed in the U.S. in 2004. In the non-surgical treatment of localized prostate cancer, fiberoptically delivered interstitial laser thermal therapy may be ideal for treating discrete tumors with minimal invasiveness. Real-time magnetic resonance imaging can be used to compute temperature changes based on the proton resonance frequency (PRF) shift, and two-dimensional maps of temperature rise and chronic thermal damage can be constructed in order to control laser therapy. In this work, we describe an MRI-compatible percutaneous grid template and localization and planning software for precise placement of minimally invasive laser catheters to effect a target ablation zone. We evaluated the accuracy of the catheter placement, and we present our preliminary experience with percutaneous MRI-guided feedback controlled laser ablation in a canine prostate model. Histological analysis is used to assess the effectiveness and accuracy of treatment visualization.

Paper Details

Date Published: 25 April 2005
PDF: 12 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.587747
Show Author Affiliations
Roger J. McNichols, BioTex, Inc. (United States)
Ashok Gowda, BioTex, Inc. (United States)
Marc D. Gelnett, BioTex, Inc. (United States)
Roger J. Stafford, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong; Eugene A. Trowers; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Reza S. Malek; Henry Hirschberg; Kenneth Eugene Bartels; Steen J. Madsen; Lloyd P. Tate; Lawrence S. Bass; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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