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Proceedings Paper

Design and fabrication of disposable percutaneous chemical sensors
Author(s): Kuo-Chih Liao; Thieo Hogen-Esch; Frances J. Richmond; Laura Marcu; Gerald E. Loeb
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Paper Abstract

Sencils (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophors bound to dextran and Concanavalin-A in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-500mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

Paper Details

Date Published: 23 March 2005
PDF: 17 pages
Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005); doi: 10.1117/12.587668
Show Author Affiliations
Kuo-Chih Liao, Univ. of Southern California (United States)
Thieo Hogen-Esch, Univ. of Southern California (United States)
Frances J. Richmond, Univ. of Southern California (United States)
Laura Marcu, Univ. of Southern California (United States)
Gerald E. Loeb, Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 5691:
Optical Fibers and Sensors for Medical Applications V
Israel Gannot, Editor(s)

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