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Proceedings Paper

Gold nanoparticles: a novel application of spectral imaging in proteomics - preliminary results
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Paper Abstract

The intense research in proteomics is demanding for fast, reliable and easy-to-use methods in order to study the proteome. In this proceeding we report the development of such a novel research tool based on spectral imaging and Resonance Light Scattering gold particles. This method will allow the study of DNA-protein interactions. We suggest a broad range of applications: the screening of proteins binding to a specific DNA sequence, the analysis of binding affinities between protein and DNA, and the investigation of the influence of environmental conditions on the binding. We will explain the principle, first experiments and first results based on Brownian motion.

Paper Details

Date Published: 23 March 2005
PDF: 8 pages
Proc. SPIE 5694, Spectral Imaging: Instrumentation, Applications, and Analysis III, (23 March 2005); doi: 10.1117/12.587517
Show Author Affiliations
Heidelinde Regina Christina Dietrich, Delft Univ. of Technology (Netherlands)
Ian Ted Young, Delft Univ. of Technology (Netherlands)
Yuval Garini, Delft Univ. of Technology (Netherlands)

Published in SPIE Proceedings Vol. 5694:
Spectral Imaging: Instrumentation, Applications, and Analysis III
Gregory H. Bearman; Anita Mahadevan-Jansen; Richard M. Levenson M.D., Editor(s)

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