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Proceedings Paper

Adaptation of nanoarrays for the study of α-synuclein aggregation: preliminary results
Author(s): Heidelinde Regina Christina Dietrich; Richard L. van den Doel; Wolfgang Hoyer; Wim van Oel; Guus Liqui Lung; Yuval Garini; Thomas Jovin; Ian T. Young
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Paper Abstract

In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein α-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications.

Paper Details

Date Published: 29 March 2005
PDF: 8 pages
Proc. SPIE 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III, (29 March 2005); doi: 10.1117/12.587493
Show Author Affiliations
Heidelinde Regina Christina Dietrich, Technische Univ. Delft (Netherlands)
Richard L. van den Doel, Technische Univ. Delft (Netherlands)
Wolfgang Hoyer, Max-Planck-Institut fuer Biophysikalische Chemie (Germany)
Wim van Oel, Technische Univ. Delft (Netherlands)
Guus Liqui Lung, Technische Univ. Delft (Netherlands)
Yuval Garini, Technische Univ. Delft (Netherlands)
Thomas Jovin, Max-Planck-Institut fuer Biophysikalische Chemie (Germany)
Ian T. Young, Technische Univ. Delft (Netherlands)


Published in SPIE Proceedings Vol. 5699:
Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III
Dan V. Nicolau; Dan V. Nicolau; Jörg Enderlein; Ramesh Raghavachari; Robert C. Leif; Daniel L. Farkas, Editor(s)

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