Share Email Print
cover

Proceedings Paper

Adaptation of nanoarrays for the study of alpha-synuclein aggregation: preliminary results
Author(s): Heidelinde Regina Christina Dietrich; Richard L. van den Doel; Wolfgang Hoyer; Wim van Oel; Guus Liqui Lung; Yuval Garini; Thomas Jovin; Ian T. Young
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein α-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications.

Paper Details

Date Published: 29 March 2005
PDF: 8 pages
Proc. SPIE 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III, (29 March 2005); doi: 10.1117/12.587493
Show Author Affiliations
Heidelinde Regina Christina Dietrich, Technische Univ. Delft (Netherlands)
Richard L. van den Doel, Technische Univ. Delft (Netherlands)
Wolfgang Hoyer, Max-Planck-Institut fuer Biophysikalische Chemie (Germany)
Wim van Oel, Technische Univ. Delft (Netherlands)
Guus Liqui Lung, Technische Univ. Delft (Netherlands)
Yuval Garini, Technische Univ. Delft (Netherlands)
Thomas Jovin, Max-Planck-Institut fuer Biophysikalische Chemie (Germany)
Ian T. Young, Technische Univ. Delft (Netherlands)


Published in SPIE Proceedings Vol. 5699:
Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III
Dan V. Nicolau; Dan V. Nicolau; Jörg Enderlein; Ramesh Raghavachari; Robert C. Leif; Daniel L. Farkas, Editor(s)

© SPIE. Terms of Use
Back to Top