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Proceedings Paper

Characterization of thermally induced transitions of collagen using second harmonic generation (SHG) microscopy
Author(s): Yen Sun; Chih-Yuan Hsiao; Shu-Wen Teng; Wen Lo; Hsian-Yuan Tan; Sung-Jan Lin; Gwo-Jen Jan; Wei-Chou Lin; Shiou-Hwa Jee; Chen-Yuan Dong
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Paper Abstract

As a major component of the connective tissues, collagen fibers are responsible for various physiological functions inside the body. They provide support for the skin, partial focusing through the cornea, and coordinate movements via tendons, ligaments, and cartilages. In many medical procedures, thermal reorganization of the collagen structure is inevitable or desired. Therefore, the optimization of the therapeutic values of these procedures requires the characterization of thermal changes to collagen fibers. In this presentation, we use multiphoton microscopy to achieve this task. We will show that second harmonic generation (SHG) microscopy can characterize the thermally altered states of collagen and that they have potentials to be used in imaging applications in vivo.

Paper Details

Date Published: 14 April 2005
PDF: 8 pages
Proc. SPIE 5698, Thermal Treatment of Tissue: Energy Delivery and Assessment III, (14 April 2005); doi: 10.1117/12.587176
Show Author Affiliations
Yen Sun, National Taiwan Univ. (Taiwan)
Chih-Yuan Hsiao, National Taiwan Univ. (Taiwan)
Shu-Wen Teng, National Taiwan Univ. (Taiwan)
Wen Lo, National Taiwan Univ. (Taiwan)
Hsian-Yuan Tan, Chang Gung Memorial Hospital (Taiwan)
Sung-Jan Lin, National Taiwan Univ. (Taiwan)
Gwo-Jen Jan, National Taiwan Univ. (Taiwan)
Wei-Chou Lin, National Taiwan Univ. (Taiwan)
Shiou-Hwa Jee, National Taiwan Univ. (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 5698:
Thermal Treatment of Tissue: Energy Delivery and Assessment III
Thomas P. Ryan, Editor(s)

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