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Proceedings Paper

Measurement of hemoglobin saturation in tumor microvasculature in preclinical models using hyperspectral imaging
Author(s): Brian S. Sorg; Benjamin J. Moeller; Owen Donovan; Yiting Cao; Mark W. Dewhirst
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Paper Abstract

Tumor hypoxia has been shown to be of prognostic value in several clinical trials involving radiation, chemotherapy, and surgery. Studies of tumor oxygenation at the microvascular and microregional levels can provide understanding of tumor oxygen transport on scales comparable to the diffusion distance of oxygen in tissue. To fully grasp the significance of blood oxygen delivery and hypoxia at the microvascular level, the spatial and temporal relationship of blood oxygenation data must be preserved and mapped. Using tumors grown in dorsal skin-fold window chamber models, hyperspectral imaging can provide spatial maps of blood oxygenation in terms of hemoglobin saturation at the microvascular level, and these measurements can be performed serially in the same animal in a non-invasive fashion with relative technical ease. A hyperspectral imaging system has been constructed to create image maps of hemoglobin saturation in microvasculature of tumors grown in dorsal skin-fold window chambers. Preliminary baseline studies of early tumor development using 4T1 mouse mammary carcinomas are currently being conducted with the system.

Paper Details

Date Published: 23 March 2005
PDF: 8 pages
Proc. SPIE 5694, Spectral Imaging: Instrumentation, Applications, and Analysis III, (23 March 2005); doi: 10.1117/12.585520
Show Author Affiliations
Brian S. Sorg, Duke Univ. Medical Ctr. (United States)
Benjamin J. Moeller, Duke Univ. Medical Ctr. (United States)
Owen Donovan, Duke Univ. (United States)
Yiting Cao, Duke Univ. Medical Ctr. (United States)
Mark W. Dewhirst, Duke Univ. Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 5694:
Spectral Imaging: Instrumentation, Applications, and Analysis III
Gregory H. Bearman; Anita Mahadevan-Jansen; Richard M. Levenson, Editor(s)

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