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Proceedings Paper

Photodynamic destruction of Porphyromonas gingivalis induced by delta-aminolaevulinic acid
Author(s): Aleksander Sieron; Andrzej Wiczkowski; Mariusz Adamek; Lucja Dyla; Sebastian Mazur; Beata Wierucka-Mlynarczyk
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Paper Abstract

Photodynamic therapy (PDT) is one of a novel modalities which has recently been exploited to eradicate various microorganisms. In our study we have evaluated bactericidal efficacy of PDT in the presence of 5-δ aminolaevulinic acid (ALA). Porphyromonas gingivalis were incubated with increasing concentration of ALA and subsequently irradiated by progressive light doses. Complete killing effect was obtained for bacteria irradiated with 25J/cm2 in ALA solution final concentration of 1mM, 5mM, 10mM. Statistical analysis has revealed ALA concentration to be a major factor responsible for eradication of bacteria. The latter may be attributable to the known ALA dark toxicity.

Paper Details

Date Published: 10 September 2004
PDF: 6 pages
Proc. SPIE 5610, Laser Florence 2003: A Window on the Laser Medicine World, (10 September 2004); doi: 10.1117/12.584427
Show Author Affiliations
Aleksander Sieron, Silesian Medical Univ. (Poland)
Andrzej Wiczkowski, Silesian Medical Univ. (Poland)
Mariusz Adamek, Silesian Medical Univ. (Poland)
Lucja Dyla, Silesian Medical Univ. (Poland)
Sebastian Mazur, Silesian Medical Univ. (Poland)
Beata Wierucka-Mlynarczyk, Silesian Medical Univ. (Poland)

Published in SPIE Proceedings Vol. 5610:
Laser Florence 2003: A Window on the Laser Medicine World
Leonardo Longo; Alfons G. Hofstetter; Mihail-Lucian Pascu; Wilhelm R. A. Waidelich, Editor(s)

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